Recently, Shenzhen Meili Nanopore Technology Co., Ltd. (hereinafter referred to as“ Meili Technology” ）In collaboration with a research team from Southern University of Science and Technology, we have published important research results in the top tier journal in the field of materials science, Advanced Functional Materials (Impact Factor 19.0). For the first time, we have revealed the breakthrough ability of AcGspD, a pancreatic secretion protein derived from acidophilic bacteria, as a novel nanopore in ion selective screening and single-molecule sensing. This study marks a crucial step forward for Meili Technology in the development and application of nanopore protein technology.